The POPPI Trial - results now published!



Society of Critical Care Medicine Annual Congress and

The Journal of the American Medical Association


It is increasingly recognised that high numbers of critically ill patients develop longer-term psychological morbidity following a stay in the critical care unit. POPPI, carried out in 24 UK critical care units and which included 1,458 critically ill patients, set out to evaluate whether an early, nurse-led, preventive, complex psychological intervention reduces the development of patient-reported post-traumatic stress disorder symptom severity at six months.

We can confirm that the results of POPPI were presented by Professor Kathy Rowan on 18 February 2019 at the Society of Critical Care Medicine (SCCM) 48th Annual Congress in San Diego, United States. Simultaneously, the results were published online in the Journal of the American Medical Association (JAMA) – the article can be viewed on the JAMA website at the following link:

https://jamanetwork.com/journals/jama/fullarticle/2725208

POPPI - led by Professor Rowan as Chief Investigator - was funded by the National Institute for Health Research – Health Services & Delivery Research Programme and is a collaboration between researchers and clinicians from ICNARC, The London School of Hygiene and Tropical Medicine and University College London Hospitals NHS Foundation Trust.

We would like to say a big thanks to all of the patients who took their time to participate in this trial. We also thank our participating sites, and in particular our dedicated POPPI nurses, for their commitment and enthusiasm, without which this trial would not have been possible.

Published: 21 February 2019


POPPI was funded by the National Institute for Health Research (NIHR) Health Services and Delivery Research (HS&DR) Programme (project number: 12/64/124). The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HS&DR Programme, NIHR, NHS or the Department of Health.

  • Authors: Mason AJ, Grieve RD, Richards-Belle A, Mouncey PR, Harrison DA, Carpenter JR Title: A framework for extending trial design to facilitate missing data sensitivity analyses Publication: BMC Medical Research Methodology Journal website PubMed citation
  • Authors: Mason AJ, Grieve RD, Richards-Belle A, Mouncey PR, Harrison DA, Carpenter JR Title: A framework for extending trial design to facilitate missing data sensitivity analyses Publication: BMC Medical Research Methodology Journal website PubMed citation
  • Authors: Mouncey PR, Wade D, Richards-Belle A, Sadique Z, Wulff J, Grieve R, Emerson LM, Brewin CR, Harvey S, Howell D, Hudson N, Khan I, Mythen M, Smyth D, Weinman J, Welch J, Harrison DA, Rowan KM Title: A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT Publication: Health Services and Delivery Research Journal website PubMed citation
  • Authors: Wade DM, Mouncey PR, Richards-Belle A, Wulff J, Harrison DA, Sadique MZ, Grieve RD, Emerson LM, Mason AJ, Aaronovitch D, Als N, Brewin CR, Harvey SE, Howell DCJ, Hudson N, Mythen MG, Smyth D, Weinman J, Welch J, Whitman C, Rowan KM; POPPI Trial Investigators Title: Effect of a Nurse-Led Preventive Psychological Intervention on Symptoms of Posttraumatic Stress Disorder Among Critically Ill Patients Publication: JAMA Journal website PubMed citation
  • Authors: Wade D, Als N, Bell V, Brewin C, D'Antoni D, Harrison DA, Harvey M, Harvey S, Howell D, Mouncey PR, Mythen M, Richards-Belle A, Smyth D, Weinman J, Welch J, Whitman C, Rowan KM; on behalf of the POPPI Investigators Title: Providing psychological support to people in intensive care: development and feasibility study of a nurse-led intervention to prevent acute stress and long-term morbidity Publication: BMJ Open Journal website PubMed citation
  • Authors: Richards-Belle A, Mouncey PR, Wade D, Brewin CR, Emerson LM, Grieve R, Harrison DA, Harvey S, Howell D, Mythen M, Sadique Z, Smyth D, Weinman J, Welch J, Rowan KM; POPPI Trial Investigators Title: Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients (POPPI): protocol for a cluster-randomised clinical trial of a complex intervention Publication: BMJ Open Journal website PubMed citation
  • Authors: Wulff J, Sadique Z, Grieve R, Howell D, Mouncey P, Wade D, Rowan KM, Harrison DA; POPPI Trial Investigators Title: Psychological outcomes following a nurse-led preventative psychological intervention for critically ill patients trial: Statistical and health economic analysis plan Publication: Journal of the Intensive Care Society Journal website

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