REMAP-CAP

Sites open

Global: 246  UK: 138

Patients randomised (all)

Global: 1393 UK: 571

Patients randomised (COVID-19)

Global: 798 UK: 501

Individual COVID-19 site recruitment is available here. Last updated 07/08/2020, 12:30

What is this study about?

REMAP-CAP is an international (15 countries) adaptive platform trial in community acquired pneumonia, that was specifically designed to be employed in a pandemic to evaluate multiple interventions simultaneously in critically ill patients. In addition to recruiting patients with community acquired pneumonia who have been admitted to critical care, we are also recruiting patients with COVID-19 to understand optimal treatment strategies.

The trial is modular so that new domains (groups of similar treatment options) can be added over time.

COVID-19 treatment domains:

• Antivirals 
  Four interventions: (1) no antiviral; (2) lopinavir/ritonavir; (3) hydroxychloroquine; (4) lopinavir/ritonavir and hydroxychloroquine combination – Interventions including hydroxychloroquine are no longer open for recruitment
• immunomodulation
  Five interventions: (1) no immune modulation (2) interferon beta 1a (3) interleukin 1 receptor antagonist [anakinra] (4 and 5) interleukin 6 inhibition [tocilizumab and sarilumab]
• Immunoglobulin therapy
  Two interventions: (1) no immunoglobulin; (2) convalescent plasma
• Therapeutic anticoagulation
  Two interventions: (1) local standard venous thromboprophylaxis (2) therapeutic anticoagulation with intravenous unfractionated heparin or subcutaneous low molecular weight heparin
• Vitamin C
  Two interventions: (1) no vitamin C; (2) vitamin C
• Statin therapy
  Two interventions: (1) no statin therapy (2) simvastatin
• Corticosteroids (three interventions: (1) no steroids; (2) steroids for 7 days (3) steroids if shock present) – no longer open for recruitment

Community Acquired Pneumonia treatment domains:

• Antibiotics
  Five interventions: (1) Ceftriaxone + Macrolide; (2) Moxifloxacin or Levofloxacin; (3) Piperacillin-tazobactam + Macrolide (4) Ceftaroline + Macrolide (5) Amoxicillin-clavulanate + Macrolide
• Macrolide duration
  Two interventions: (1) standard course (3-5 days); (2) extended course (14 days)
• Corticosteroids
  Three interventions: (1) no steroids; (2) steroids for 7 days (3) steroids if shock present
• Antivirals (influenza)
  Three interventions: (1) no antiviral for influenza; (2) Oseltamivir (5 days); (3) Oseltamivir (10 days)
• Vitamin C
  Two interventions: (1) no vitamin C; (2) vitamin C

 Further information can be found on the global REMAP-CAP website https://www.remapcap.org

 

Information for sites

Information is available for participating sites on set-up, randomisation, pharmacy arrangements and FAQs.