REMAP-CAP

Sites open

Global: 312  UK: 143

Patients randomised (all)

Global: 7139 UK: 4500

Patients randomised (COVID-19)

Global: 6361 UK: 4417

Individual COVID-19 site recruitment is available here. 

What is this study about?

REMAP-CAP is an international (15 countries) adaptive platform trial in community acquired pneumonia, that was specifically designed to be employed in a pandemic to evaluate multiple interventions simultaneously in critically ill patients. In addition to recruiting patients with community acquired pneumonia who have been admitted to critical care, we are also recruiting patients with COVID-19 to understand optimal treatment strategies.

The trial is modular so that new domains (groups of similar treatment options) can be added over time.

COVID-19 treatment domains:

Ward and ICU

• Antiplatelet Three interventions: (1) no antiplatelet; (2) aspirin; (3) P2Y12 inhibitor (clopidogrel, prasugrel or ticagrelor)

ICU only

• Vitamin C Two interventions: (1) no vitamin C; (2) vitamin C

• Statin therapy Two interventions: (1) no statin therapy; (2) simvastatin

• ACE-2 RAS Four interventions: (1) no RAS; (2) Angiotensin converting enzyme inhibitor (ACEi); (3) Angiotensin-II receptor blocker (ARB); (4) ARB in combination with DMX-200, a chemokine receptor-2 (CCR2) inhibitor

• Anticoagulation No prior therapeutic anticoagulation - Two interventions: (1) Conventional low dose thromboprophylaxis; (2) Intermediate dose thromboprophylaxis  Prior therapeutic anticoagulation - Three interventions: (1) Conventional low dose thromboprophylaxis; (2) Intermediate dose thromboprophylaxis; (3) Continuation of therapeutic dose anticoagulation

 Domains closed/paused to recruitment:

• Corticosteroids (1) Letter to sites 13JUL2020; (2) JAMA publication – Effect of Hydrocortisone on Mortality and Organ Support in Patients with Severe COVID-19

• Antivirals (1) Letter to sites 13JUL2020; (2) Letter to sites 19NOV2020

• Immunoglobulin therapy (1) Letter to sites 07JAN2021

• Therapeutic anticoagulation  (1)Letter to sites 19DEC2020; (2) Letter to sites 08JAN2021; (3) Letter to sites 22JAN2021; (4) ATTACC, ACTIV-4a & REMA-CAP Multiplatform RCT: Results of Interim Analysis)

• Immune modulation (1) Press release 19NOV2020; (2) Letter to sites 07JAN2021; (3) NEJM publication - Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19; (4) Letter to sites 09APR2021

Community Acquired Pneumonia treatment domains:

• Antibiotics Five interventions: (1) Ceftriaxone + Macrolide; (2) Moxifloxacin or Levofloxacin; (3) Piperacillin-tazobactam + Macrolide (4) Ceftaroline + Macrolide (5) Amoxicillin-clavulanate + Macrolide

• Macrolide duration Two interventions: (1) standard course (3-5 days); (2) extended course (14 days)

• Corticosteroids Three interventions: (1) no steroids; (2) steroids for 7 days (3) steroids if shock present

• Antivirals (influenza) Three interventions: (1) no antiviral for influenza; (2) Oseltamivir (5 days); (3) Oseltamivir (10 days)

• Vitamin C Two interventions: (1) no vitamin C; (2) vitamin C

Further information can be found on the global REMAP-CAP website https://www.remapcap.org

COVID-19 newsletter:

• UK REMAP-CAP Pandemic Newsletter (No. 2) 
• Global REMAP-CAP Newsletter (No. 11)

Information for sites

Information is available for participating sites on set-up, randomisation, pharmacy arrangements and FAQs.

Chief Medical Officers' letter of support

REMAP-CAP has been named as one of the three national randomised trials in COVID-19. Please find the letter of support encouraging participation of all hospitals into these studies.

Registration

REMAP-CAP is registered NCT02735707
EudraCT number: 2015-002340-14

Funding and support