REMAP-CAP

A Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired Pneumonia

                            




Sites open

Global: 332  UK: 143

Patients randomised (all)

Global: 11,519 UK: 5,666

Patients randomised (COVID-19)

Global: 9,945 UK: 5,539

 

What is this study about?

REMAP-CAP is an international (15 countries) adaptive platform trial in community acquired pneumonia, that was specifically designed to be employed in a pandemic to evaluate multiple interventions simultaneously in critically ill patients. In addition to recruiting patients with community acquired pneumonia who have been admitted to critical care, we are also recruiting patients with COVID-19 to understand optimal treatment strategies.

The trial is modular so that new domains (groups of similar treatment options) can be added over time.

COVID-19 treatment domains
:

ICU only

  • Statin Two interventions: (1) No statin therapy; (2) Simvastatin
  • Anticoagulation 
    • No prior therapeutic anticoagulation - Two interventions: (1) Conventional low dose thromboprophylaxis; (2) Intermediate dose thromboprophylaxis 
    • Prior therapeutic anticoagulation - Three interventions: (1) Conventional low dose thromboprophylaxis; (2) Intermediate dose thromboprophylaxis
  • Cysteamine Two interventions: (1) No cysteamine; (2) Cysteamine

ICU and Ward

  • Updated Immunoglobulin Two interventions: (1) High titer convalescent plasma; (2) No immunoglobulin


Domains closed/paused to recruitment:

  • Continuation of therapeutic dose anticoagulation (1) Letter to sites 06JUL2022

Community Acquired Pneumonia treatment domains:

  • Antibiotics Five interventions: (1) Ceftriaxone + Macrolide; (2) Moxifloxacin or Levofloxacin; (3) Piperacillin-tazobactam + Macrolide (4) Ceftaroline + Macrolide (5) Amoxicillin-clavulanate + Macrolide
  • Macrolide duration Two interventions: (1) Standard course (3-5 days); (2) Extended course (14 days)
  • Corticosteroids Three interventions: (1) No steroids; (2) Steroids for 7 days (3) Steroids if shock present
  • Antivirals (influenza) Three interventions: (1) No antiviral for influenza; (2) Oseltamivir (5 days); (3) Oseltamivir (10 days)
  • Cysteamine Two interventions: (1) No cysteamine; (2) Cysteamine

 

Domains closed/paused to recruitment:


Further information can be found on the global REMAP-CAP website https://www.remapcap.org

COVID-19
Summary of study results (19MAY2021)


Information for sites

Information is available for participating sites on set-up, randomisation, pharmacy arrangements and FAQs.

Chief Medical Officers' letter of support

REMAP-CAP has been named as one of the three national randomised trials in COVID-19. Please find the letter of support encouraging participation of all hospitals into these studies.

Registration 

REMAP-CAP is registered: NCT02735707
EudraCT number: 2015-002340-14

Funding and support

European Commission FP7: Platform foR European Preparedness Against (Re-)emerging Epidemics
Prioritised by the NIHR as a COVID19 study
 

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