COVID-19 slidesets: 

1) Complete set of set-up slides
2) Slideset focussed on individual domains 
         - introduction of moderate state
         - Statins domain
         - Antiplatelet domain
         - Vitamin C domain 
3) GCP training for ward-based staff
4) ATTACC, ACTIV-4a & REMAP-CAP Multiplatform RCT: Results of Interim Analysis 
5) REMAP-CAP IL-6 Receptor Antagonist Domain Results Livestream
6) Anticoagulation domain amendment
7) Anticoagulation domain update webinar
8) ACE-2 RAS domain
9) ACE-2 RAS domain webinar
10) Cysteamine domain slides
11) Cysteamine domain video

CAP slidesets: 

1) Initiation slides
         - Backgound & design
         - Eligibility
         - Delivery of intervention
         - Consent
         - Data collection 
         - Start-up
2) Summary of changes
3) Pandemic appendix to core protocol
4) Domains
         - Antibiotic
         - Macrolide duration
         - Corticosteroid
         - Antiviral (influenza)
         - Vitamin C

WE4YOU seminars:

Recordings of WE4YOU seminars can be accessed here.


REMAP-CAP: Adaptive and Multifactorial


DMX-200 training pack: 

The DMX-200 training pack can be downloaded here

REMAP-CAP trial clinicians can now be accredited through the NIHR Associate Principal Investigator Scheme 

What is it about?

Clinicians involved with the Randomised Embedded Multifactorial Adaptive Platform Trial for Community Acquired Pneumonia (REMAP-CAP) are now able to take part in the Associate Principal Investigator (PI) Scheme. Under the guidance of an experienced mentor, participants in the scheme can develop their skills and understanding of clinical trial research. This leads to a formal qualification that recognises their engagement and participation in research activities. The aim is that this will help to train the PIs of the future.

Who can participate?

Any clinician (e.g. junior doctors, Allied Health Professionals etc.) who expects to make a significant contribution to the conduct and delivery of REMAP-CAP at a local level for at least six months from now can sign up to complete the Associate PI Scheme. Interested applicants must initially discuss and obtain approval from the local PI and Clinical Trials Unit before registering for the scheme.

How do I register for the scheme?

You can register by completing the online Associate PI Scheme Registration Form on the NIHR website. You will then receive a welcome pack with a checklist of activities to complete under the supervision of your local PI. These activities include recruiting patients; reviewing protocols; participating in research team meetings; and study dissemination. Once the activities have been completed and the checklist has been signed off by your local PI mentor, you will receive an NIHR-endorsed certificate and are then free to register to another study at the same or another site.

What are the potential benefits?

It is anticipated that the Associate PI Scheme will bring multiple benefits for REMAP-CAP.  The skills taught in the training scheme will help to boost recruitment rates, allowing the research questions in the trial to be answered more quickly and efficiently. Meanwhile, the trainees benefit in terms of their CVs and receiving high quality research training and exposure 'on the job'. Finally, NHS patients themselves benefit, since embedding research into clinical practice will ensure that clinical care is based on high-quality evidence.’

How will the scheme operate in REMAP-CAP?

Clinicians who wish to understand how the Associate PI Scheme will operate within the context of REMAP-CAP can learn more from an introductory video: Available here.

Who manages the scheme?

The Associate PI Scheme is managed through the NIHR.  The Associate PI status is endorsed by the NIHR and the following medical Royal Colleges: Royal College of Anaesthetists; Royal College of Emergency Medicine; Royal College of Physicians; Faculty of Intensive Care Medicine; Royal College of Radiologists; and the Royal College of Surgeons (England). Further information is available on the NIHR website

Who should I contact if I have any questions?

If you have any questions about the scheme, please contact the Associate PI Scheme Central Team at


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