ProMISe: Protocolised Management In Sepsis


Sepsis is a severe infection in the blood which can damage important organs in the body, such as the heart and lungs. Patients who develop sepsis are at a high risk of dying. A research study in a US hospital emergency department found that patients with sepsis treated using a 6-hour resuscitation protocol (compared with usual treatment) were more likely to survive and to spend less time in hospital. The ProMISe study wanted to find out if the 6-hour resuscitation protocol would work in the UK, compared with usual treatment.


A total of 1260 patients from 56 hospitals across the country took part in the study. Patients were evenly split into two groups to receive either the 6-hour resuscitation protocol or usual treatment. They were followed up for 1 year to see the long-term effects of receiving treatment.


There was no significant difference in the number of patients who died after 90 days or after 1 year of receiving either treatment. The costs of treatment (in hospital and after leaving hospital) were higher for patients who received the 6-hour resuscitation protocol.


The 6-hour resuscitation protocol did not improve survival for patients with sepsis and was more expensive.

Who led the study?

Professor Kathy Rowan, ICNARC

This study was funded by the National Institute for Health Research (NIHR) – Health Technology Assessment (HTA) Programme (Project: 07/37/47)


Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter R, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AH, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, Yealy DM. Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. N Engl J Med 2017; .

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Reade MC, Delaney A, Bailey MJ, Harrison DA, Yealy DM, Jones PG, Rowan KM, Bellomo R, Angus DC. Prospective meta-analysis using individual patient data in intensive care medicine. Intensive Care Med 2010; 36(1):11-21.

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